Glutamyl transpeptidase 1800+ U/L is generally more serious, usually considered to be related to liver cirrhosis, gallbladder stones, viral hepatitis and other diseases, need to go to the hospital for further examination to clarify the cause of the disease, and then consult the doctor in time. 1. Cirrhosis: It is usually due to liver cell damage caused by cirrhosis, which leads to cholestasis and high glutamyl transpeptidase. Cirrhosis may cause abdominal discomfort, fatigue, loss of appetite and other symptoms, which can be treated with medicines such as silymarin capsules and furosemide tablets under the guidance of a doctor. 2. Gallbladder stones: It is usually due to stones, leading to abnormalities in fat metabolism and gallbladder function, which cause high glutamyl transpeptidase. Gallbladder stones usually cause epigastric pain, nausea and other symptoms, and can be treated with surgery such as laparoscopic cholecystectomy under the guidance of a doctor. 3. Viral hepatitis: It may be due to viral hepatitis that causes damage to liver cells, resulting in high glutamyl transpeptidase. Viral hepatitis usually causes epigastric discomfort and other symptoms, and can be treated with medicines such as entecavir tablets and tenofovir disoproxil fumarate tablets as prescribed by the doctor. If the phenomenon of glutamyl transpeptidase is too high, you should go to the hospital, after clarifying the cause to give targeted treatment, under the guidance of the doctor to use drugs, not blindly use drugs, daily life, should pay attention to rest, appropriate exercise.