Whether nifedipine extended-release tablets can be replaced with amlodipine depends on the specific situation. Generally, it is possible to replace nifedipine extended-release tablets with amlodipine to treat high blood pressure, but the dose needs to be adjusted according to the doctor’s instructions, nifedipine extended-release tablets are medium-acting drugs, the duration of the drug effect is within 12 hours, and not up to 24 hours. Amlodipine is generally a long-acting drug that lasts up to 24 hours. 1. Nifedipine extended-release tablets: mainly applicable to the treatment of various types of hypertension, but prohibited for allergy to drug components; pregnant women within 20 weeks of pregnancy and lactating women; patients with cardiogenic shock. The main adverse reactions are hypotension, palpitations (rapid heartbeat, often accompanied by panic), peripheral edema, facial flushing, nausea, abdominal distension, diarrhea, gingival hyperplasia, dizziness, headache and so on. 2. Amlodipine: It is mainly used for the treatment of hypertension and coronary heart disease, but is prohibited for those who are allergic to the ingredients of the drug; patients with severe hypotension; patients with severe aortic stenosis. The main adverse reactions include flushing, palpitations (rapid heartbeat, often accompanied by panic), peripheral edema, abdominal pain, nausea, dizziness, headache, drowsiness, fatigue and so on. For hypertensive patients during pregnancy and lactation, amlodipine can be used, but nifedipine extended-release tablets are not recommended. Patients with hypertension should go to the cardiovascular medicine department of regular hospitals and take the medication as prescribed by the doctor.