The full dose of rabies vaccine is usually five shots, and only three shots of rabies vaccine will produce a certain amount of antibodies and will be able to maintain a certain concentration, but it will last for a shorter period of time. For normal people antibodies are produced when the first shot is given, but the amount of antibodies is not stable and is not large enough. Generally, four or five shots are needed to protect against the rabies virus. Generally, after five shots, you will be protected from the rabies virus for one year. A booster shot can extend the effect to three years, and a second booster shot can provide even longer immunity. Rabies is a malignant and contagious disease and it is recommended that the full five doses of the vaccine be given if there is a high risk of infection.