The best topical medications for perianal eczema include calcium-modulated phosphatase inhibitors, glucocorticoid drugs, local cleansing, and adsorption of exudates. The effect also varies from person to person, can not be generalized, there is no such thing as the best drug. 1. Calcium-modulated phosphatase inhibitors: the specific cause of perianal eczema has not been fully clarified, and is considered to be related to the combined effect of internal and external factors. It is recommended to remove the adverse stimuli, under the guidance of the doctor to give tacrolimus, pimecrolimus and other calcium-modulating phosphatase inhibitors treatment. 2. Glucocorticoid drugs: glucocorticoid drugs can inhibit the local inflammatory response, if necessary, with hydrocortisone butyrate ointment, halomethasone ointment topical application, can control the inflammatory response. 3. Local cleaning, adsorption of exudate: commonly used boric acid solution, potassium permanganate solution, etc. Perianal eczema, is a skin problem, it is recommended to go to the hospital dermatology department, under the guidance of the doctor with medication.