Getting up every morning with a dry, bitter mouth may be related to oral disease, bile reflux, medications, etc. 1. Poor oral hygiene: If the oral hygiene environment is relatively poor, food debris, soft dirt, bacteria, etc., a large number of accumulation on the tooth surface and tongue surface, debris itself corruption or bacterial reproduction, will lead to the mouth bitter, dry. 2. Bile reflux: For example, cholecystitis, an inflammatory lesion of the gallbladder caused by bacterial infection or chemical irritation. When bile reflux occurs, dry and bitter mouth may occur. 3. Medications: for example, clarithromycin, after taking the drug, due to the side effects of the drug, may appear in the morning get up dry mouth, bitter mouth and other discomforts. When dry mouth and bitter mouth appear every morning, it is recommended to consult a doctor in time, follow the doctor’s instructions for further examination, clarify the cause with the help of the doctor, and carry out targeted treatment or therapy.