HFMD can be prevented by both direct and indirect prevention. If there are babies with similar HFMD rashes at home or in learning institutions, etc., they should be isolated and treated to avoid contact with such babies. Toys and tableware used by these babies should be sterilized. Secondly, there is currently no clinically stable vaccine for HFMD, therefore, clinical prevention focuses mainly on the prevention of severe HFMD. The common type of HFMD tends to have only herpes on the hands, feet, buttocks, and inside the mouth. It can mostly get better with symptomatic supportive treatment as prescribed by the doctor. However, if the baby shows signs of neurological involvement, such as bulging fontanel and neck obstruction, we need to be highly alert to the possibility of severe HFMD. We need to hospitalize the baby in a timely manner and follow the doctor’s instructions to reduce intracranial pressure and limit the amount of fluid intake and other treatments. It is recommended to give the baby more hand washing, more ventilation, pay attention to environmental hygiene.