Survival period of patients with advanced lung cancer has obvious individual differences, which cannot be precisely determined, but clinically speaking, the prognosis of patients with advanced lung cancer is poor in general, and the 5-year survival rate is less than 5% in statistical analysis. Survival of patients with advanced lung cancer mainly depends on the following aspects, including whether the lung tumor has distant metastasis or not, the patient’s health condition, whether there are more basic diseases and whether regular tumor treatment is carried out. Patients with advanced lung cancer may have a longer survival period than untreated patients through targeted treatments such as radiotherapy, chemotherapy, immunotherapy and targeted therapy. Therefore, patients with advanced lung cancer should cooperate with doctor’s treatment according to their own physical condition and conditions, keep a positive mindset, and regular follow-up in regular hospitals is very necessary.