Glucocorticoids are important hormones in the body and have a greater effect on metabolic diseases, including stress and anti-inflammation. After being synthesized artificially by chemical methods, they can be used as drugs to treat diseases. The more common ones in clinical practice include dexamethasone, prednisone acetate, hydrocortisone, sodium methylprednisolone succinate for injection, etc. They have important roles in the treatment of endocrine diseases, kidney diseases, rheumatic diseases and blood diseases.1. Endocrine diseases: Common ones such as pituitary hypofunction and adrenal cortical hypofunction, etc., due to production of glucocorticoids or lack of supernumerary hormones, resulting in a lack of cortisol in the human body, which can be treated with glucocorticoid replacement and supplementation close to human secretion; 2, renal diseases: such as nephrotic syndrome, glucocorticoids prevent immune reactions from occurring by inhibiting antigenic antibody reactions in the body; 3, rheumatic diseases: for the acute phase of gouty arthritis, glucocorticoids induce vasoconstriction at the inflammation site and For rheumatic diseases: In the acute stage of gouty arthritis, glucocorticoids can reduce the vasoconstriction and capillary permeability at the inflammation site, thereby reducing local exudation, congestion, swelling and other uncomfortable symptoms; 4. Patients must use glucocorticosteroids under medical supervision and not for a long time to prevent adverse reactions such as electrolyte metabolism disorders, hyperalgesia, and osteoporosis. In addition, if patients become dependent on glucocorticosteroids, the body’s resistance may become weaker.