For the differentiation of benign and malignant bone tumor, it should be combined with clinical manifestation, imaging examination, pathological diagnosis and other aspects, and if necessary, other auxiliary examinations to make a comprehensive analysis in order to make a correct diagnosis. The following are some of the main differentiation points of benign and malignant tumors in terms of symptoms and signs for the reference of patients and family members: benign malignant Onset of disease Mass first Pain first Growth rate Slow Rapid Pain degree None or mild Moderate or severe, pain aggravated at night Systemic symptoms None Fever, emaciation, cachexia in advanced stage Mass boundary Clear Unclear, infiltration of surrounding tissues Mass surface Mostly unchanged Heat, redness and Venous filling Compression Pain None or slight Significant pressure pain