Positive anti-Jo-1 antibody is recommended for rheumatology and immunology to identify the cause of the disease. Positive anti-Jo-1 antibody can be seen in idiopathic inflammatory myopathies such as polymyositis, dermatomyositis, and the treatment is mainly drug therapy. Positive anti-Jo-1 antibody can be seen in idiopathic inflammatory myopathies such as polymyositis, dermatomyositis, etc., but the diagnosis needs to be based on the presence of limb muscle weakness, idiopathic rash, muscle biopsy, muscle enzyme profiles and other results of the comprehensive judgment, it is recommended that rheumatology and immunology department consultation. Glucocorticoids such as prednisone are preferred for idiopathic inflammatory myopathies, which usually require about 3 years of medication, and most of the patients can be in remission, and some of them are in complete remission, but they are prone to relapse. It can also be combined with immunosuppressive therapy, such as cyclosporine and tacrolimus. Those with skin damage can combine with hydroxychloroquine. The above drugs need to be used according to the doctor’s prescription. Therefore, it is recommended that anti-Jo-1 antibody positive patients should consult the rheumatology department in a timely manner, and individualized treatment should be carried out after a thorough evaluation by the doctor.