Olanzapine is not a hormonal drug, many patients will find their weight increase after using Olanzapine to treat mental illness, so they will consider Olanzapine contains hormones, but it is not so. But this is not the case. Weight gain is due to the fact that olanzapine acts on alpha and H1 receptors, causing patients to experience increased appetite, abnormal glucose and lipid metabolism, drowsiness, and other adverse effects, which further contribute to weight gain. Olanzapine and traditional hormone drugs act on completely different receptors and principles, so it can not be said that Olanzapine is a hormone-containing drugs. Adverse effects such as weight gain can be gradually reduced with functional exercise, and the patient’s weight can be gradually restored after the gradual withdrawal of the drug, so olanzapine is not a hormonal drug.