Amlodipine and Benadryl cannot be assessed as to which is better, the two drugs have different antihypertensive mechanisms and are suitable for different groups of people. Amlodipine belongs to the calcium antagonist, has the effect of dilating coronary arteries and peripheral blood vessels, is more suitable for the treatment of hypertension with coronary heart disease patients. Benazepril is an angiotensin-converting enzyme inhibitor, which has a protective effect on the kidneys and heart, and is more suitable for the treatment of hypertension with renal insufficiency and cardiac insufficiency. Amlodipine and Benadryl have different suitable people, and different patients have obvious differences in the response to the drug, the effect of the two drugs can not be assessed as good or bad, depending on which drug the patient is more suitable for taking. The adverse reactions of amlodipine include lower limb edema, dry stools, tachycardia, facial flushing, etc. It is forbidden for women who are allergic to the drug components, severe hypotension, cardiogenic shock, and lactation during pregnancy. Adverse reactions of Benadryl include dry cough, edema, dizziness, upright hypotension, etc. It is contraindicated in women who are allergic to the components of the drug, have bilateral renal artery stenosis, severe renal insufficiency, or are breastfeeding during pregnancy. Amlodipine and Benadryl in the clinical treatment of hypertension, should be used under the guidance of a physician.