They are both sexually transmitted diseases. Herpes mainly refers to genital herpes, and the causative agent of syphilis is the syphilis spirochete, which infects the body and causes syphilis. Genital herpes is caused by the herpes I virus and the herpes II virus. Among the manifestations of syphilis, recessive syphilis has no manifestations and can only be detected by a blood test. Dominant syphilis is divided into stage I syphilis, stage II syphilis, and stage III syphilis, each of which has its own manifestations. Stage I syphilis is mainly a hard chancre with swollen infiltrated lymph nodes. Stage II syphilis is mainly manifested as a skin rash of syphilis, and some syphilis rash-like changes can appear on the trunk, extremities, etc. including the oral mucosa, and if a characteristic syphilis rash appears on the hands, feet, feet and palms, it has diagnostic significance. Genital herpes, as the name implies, is a blister, usually the site of sexual contact blister, the wall is thin, inside is yellow water, stop one to two days after the break, after the break can appear pain, herpes has a primary, recurrent. There are also differences in treatment. Syphilis is mainly treated with penicillin-based drugs. Herpes is mainly treated with vaxilovir and acyclovir esters.