Taking Rosuvastatin with high hepatic bilirubin should be treated by adjusting the drug dose or changing the drug after ruling out liver disease. High hepatic bilirubin can be seen in hepatitis, gallbladder stones, cholecystitis and other diseases, in addition to taking Rosuvastatin also has a drug instruction manual clearly labeled side effects that may cause liver function damage. If high liver bilirubin occurs after taking Rosuvastatin, the adverse effects of the drug should be considered after excluding lesions of the liver itself. Side effects such as pancreatitis, skin itching, edema, myalgia, elevated aminotransferases, and jaundice hepatitis may occur during the administration of Rosuvastatin. Because the incidence of adverse reactions of Rosuvastatin has increased with the increase in dose, the dose of the drug can be adjusted or changed to other lipid-lowering drugs. The use of the drug should be prohibited in people with hypersensitivity to Rosuvastatin, active liver disease, severe renal impairment, myalgia.