Waking up with special pain in the calf may be caused by poor sleeping posture, excessive exercise, varicose veins in the lower extremities and other reasons. 1. Bad sleeping posture: If the patient keeps a posture for a long time when sleeping, it presses the calf, which will lead to ischemia of leg muscles and the symptoms of calf pain will appear after waking up. 2. Excessive exercise: If a lot of exercise is performed before going to bed, the exercise will lead to the accumulation of lactic acid in the muscles, and the feeling of calf pain will be stronger after waking up. 3. Varicose veins of the lower extremities: Patients with varicose veins of the lower extremities will experience symptoms such as heaviness, soreness, fatigue and pain in the lower extremities. It is usually caused by increased pressure in veins. Waking up with special pain in the calves may also be caused by other reasons such as lumbar disc herniation, pyriformis syndrome and lumbar spondylolisthesis, etc. It is recommended to go to the hospital in time to find out the cause of the disease and then treat the symptoms.