1, treatment object 54 male cases, 41 female cases, age 25-68 years, average 46.5 years, duration of disease 6 months-22 years, average 3.8 years, by colonoscopy and laboratory examination, confirmed the diagnosis of chronic colitis 84 cases, chronic non-specific ulcerative colitis 11 cases, stool culture with fungal growth 6 cases, the rest are not found to have other pathogenic bacteria growth. 2.Treatment method: The basic oral formula for internal treatment: self-prepared tory berry canker healing soup. Prescription: 30g each of Astragalus membranaceus, Radix et Rhizoma Polygonati, 20g each of Radix et Rhizoma Ginseng, 10g each of Radix et Rhizoma Paeoniae and Radix Angelicae Sinensis, 5g each of Radix et Rhizoma Angelicae Sinensis. For weak spleen qi, add Ginseng and Atractylodes; for deficient spleen and stomach, add Li Zhong Tang; for liver and spleen disorders, add Li Zhong Tang and Si Jun Zi Tang; for damp-heat congestion, add Bai Tou Weng Tang, reduce Huang Qi and roasted licorice, and still use after the damp-heat is mostly cleared; for liver depression and spleen and kidney yang deficiency, add Pain and Drainage, Si Jun Zi Tang and Si Shen Wan; for blood stasis, add Loss of Smile; for mixed cold and heat, add Huang Lian, Gan Jiang and Hsio Shen; for cold and dampness, add Atractylodes, Fried Atractylodes, Ginger, Hou Pu Add Cang Zhu, Fried Bai Zhu, Ginger, Hou Pu, Betel nut. Basic formula for external treatment of enema: use self-prepared bitter ginseng, Qin Yu and Bletilla intestine. Prescription: bitter ginseng 30g Qinpi 20g Diyu 20g Bletilla 10g. decoction, take the juice 150me, clean and retain the enema every night before bedtime, after the enema can not be less than 20 minutes in bed, divided into supine, prone and left and right lateral position for more than 5 minutes each, two weeks for a course of treatment, rest for a week before the second course of enema. 3, treatment effect ① light: diarrhea < 6 times a day, mainly mucus stool, abdominal pain and post-acute light, sometimes intestinal whimpering, no fever, poor appetite, hemoglobin < 10g/l, hematocrit < 20mm/h, weight loss < 3.5kg since the onset, colonoscopy: inflammation is limited to the rectum, sigmoid colon or descending colon, the mucosa is mainly congested, or there is a mild erosion ulcer 88 cases, treatment The clinical symptoms disappeared and the stool was formed in 79 cases, the clinical cure rate was 89.8%, the remaining 9 cases also had significant improvement in clinical symptoms, but the stool was still sometimes loose, 1-2 times a day. ②Heavy: diarrhea > 6 times a day, mucus in the stool, accompanied by pus and blood, abdominal pain and posterior urgency is obvious. Poor appetite, even vomiting, fever, hemoglobin <10g/L, hematocrit >30mm/h, weight loss >3.5kg since the fever, extensive inflammation or whole colon on colonoscopy, large erosive ulcers in the colon in 6 cases, clinical symptoms disappeared after treatment, stool formation in 4 cases, clinical cure rate 66.6%, 2 cases invalid, total efficiency 97.9%. The original stool culture with fungal growth, after treatment, all turned negative. According to the colonoscopy, the mucosa of the lesion is congested and edematous, or eroded, or ulcerated, covered with mucus or pus and blood secretions, with the characteristics of redness, swelling, heat, pain, ulceration and dysfunction, which is quite similar to canker sores. Spleen deficiency is the root cause of chronic diarrhea. Because spleen deficiency produces dampness, dampness can produce stasis over time, and in turn, stasis can produce dampness. Some studies have confirmed that there are microcirculatory disorders in the diseased intestinal wall, thrombosis in the blood vessels of the intestinal wall, mucosal congestion and dark red tongue as seen by enteroscopy, all of which are signs of blood stasis. According to Wu Xie-ning (1), “its immunogenetic, inflammatory process involves the interaction between a variety of metabolites and pathological products, and multiple links and factors together constitute damage to the colonic mucosa, while some inflammatory mediators and neuropeptides cause colonic motility disorders and symptoms.” These pathological products of damage to the colonic mucosa belong to the category of “toxic” evil in Chinese medicine, wetness and stagnation are toxic, wetness, stagnation and toxic evil coexist and are mutually causal, a vicious cycle, coupled with low immunity, the positive does not overcome the evil, which is the pathological basis of the disease is lingering and difficult to achieve quick results. Dampness, heat and stagnation are the symptoms of the disease. In turn, damp-heat stagnation creates stasis and toxicity, which in turn becomes the cause of the disease. The damp-heat and stagnant toxins stagnate in the intestines and fight with qi and blood, causing the intestinal conduction to fail and the ligaments to be injured. The basic formula for internal use is composed of the combined formula of “Shenxiu Tori San”, “Si Miao Yong’an Tang” and “Chi Xiao Dou Dang Gui San”, plus “Swelling Wind” and “Red Peony”. In this formula, Astragalus membranaceus and Radix et Rhizoma Glycyrrhizae strengthen the spleen and benefit the qi, and support the toxin to produce muscles; Jin Yin Hua, Radix et Rhizoma Ginseng, Radix et Rhizoma Ginseng and Radix et Rhizoma Sibiricum are good at relieving heat, stasis and dampness toxins, eliminating swelling and draining pus; Radix et Rhizoma Ginseng, Radix et Rhizoma Ginseng and Radix et Rhizoma Sibiricum can activate blood circulation and resolve blood stasis, among which Radix et Rhizoma Ginseng can dilate blood vessels. The Min Dong Materia Medica says: “Swollen ginseng can “strengthen the spleen, invigorate the blood …… and reduce swelling”. It can improve the immunity of the body, has a strong antibacterial and anti-inflammatory and tumor-expanding effect, and has a good repair effect on the non-specific inflammation of the digestive system (2). The whole formula has the function of tonifying the swelling, resolving blood stasis and removing dampness, detoxifying and draining pus, which is consistent with the pathogenesis. Modern medicine believes that the pathogenesis of chronic diarrhea is the result of the interaction of multiple links and factors, and only after the mucosal barrier is repaired, bacterial products are cleared, and a series of inflammatory chain reaction is blocked, can the mucosal tissue be repaired. Therefore, in treating chronic diarrhea with this formula, it must be applied according to the specific types of evidence by adding and subtracting, either eliminating or supporting, with one method being the main method and multiple methods being used in combination, reflecting the idea of combining evidence-based treatment and disease-based treatment, and combining macroscopic evidence-based treatment with microscopic evidence-based treatment. The external treatment method uses bitter ginseng, Qin Yu and Bletilla soup to retain the enema, which has the function of removing dampness, heat, stasis and toxicity, eliminating swelling and astringing sores, and the external treatment can also avoid the disadvantage of internal bitter cold medicine which is cold and injurious to the stomach. The formula is based on a single ingredient, Bletilla, which has the effect of both support and elimination. The Materia Medica Huiyan says: “Bletilla is an important medicine for astringency, phlegm seepage, hemostasis, and carbuncle elimination. Before the drug enema, first do a clean enema, after the enema, successively use the right side lying / left side lying / supine and prone four lying position, and each maintained for 5 to 10 minutes, is to make full contact between the drug and the intestinal wall, not only can help better play the role of external treatment drugs, but also increase the number of drugs absorbed by the large intestine, so that it directly into the large circulation, enhance the role of internal treatment drugs.