Serum ALT is short for glutamate aminotransferase, which is used to test liver function. Glutathione is found in various cells, with liver cells containing the most. When the liver undergoes acute lesions, such as poisoning or acute phase of various viral hepatitis, the liver cells are damaged and a large amount of ALT is released into the blood, and the serum ALT will rise sharply. Therefore, glutathione is the most sensitive indicator to check liver function and is an important basis for the diagnosis of hepatitis. Patients with chronic viral hepatitis will continue to or repeatedly cause mild elevation of ALT. Drugs that are toxic to the liver can also cause elevation of this enzyme, such as rifampin, isoniazid, quinine, organophosphorus, etc. It is important to monitor liver function when using or being exposed to these drugs. Because glutathione exists in many tissues and cells, there are many diseases that can also cause an increase in this enzyme, such as myocarditis, cardiomyopathy, pancreatitis, malnutrition, and skeletal muscle disease, all of which can cause an increase in glutathione activity. Therefore, it is important to actively identify the cause of elevated ALT when liver tests reveal it, and to treat it clinically and symptomatically.