The difference between acute urticaria and chronic urticaria can be distinguished from the course of the disease, accompanying symptoms, treatment, causes, and hazards to life and quality of life. 1. Duration of the disease: acute urticaria starts quickly, can last for hours and then return to normal; while chronic urticaria has a longer duration, can last for 6 weeks or even longer, recurrent, prolonged and difficult to cure. 2. Accompanying symptoms: acute urticaria can be accompanied by dyspnea, abdominal pain and even anaphylactic shock; while chronic urticaria is mainly characterized by skin erythema, itching, and seldom appears respiratory distress or anaphylactic shock. 3. Treatment: acute urticaria preferred antihistamine drugs for treatment, if the application of antihistamine drugs, the condition is not well controlled, glucocorticosteroid drugs can be used for treatment; chronic urticaria is not recommended to use hormone drugs for treatment, antihistamines, immunosuppressants and other drugs should be chosen to treat, and actively find and avoid the cause of the disease. 4. Etiology: acute urticaria is mostly caused by sensitizers or stimulation of certain physical and chemical factors; while chronic urticaria may be related to sensitizers or auto-infections, and most of the patients are unable to identify the cause of the disease. 5. Hazard to life or quality of life: acute urticaria, if the condition is severe, anaphylactic shock can occur and jeopardize the patient’s life; while chronic urticaria is usually not life-threatening, but can affect the quality of sleep and quality of life. Whether it is acute urticaria or chronic urticaria, it is recommended that patients go to the hospital, under the guidance of the doctor to choose a reasonable drug and method of treatment, they can not be indiscriminate use of drugs.