When HDL cholesterol is high, physiologic conditions generally do not require treatment, and pathologic conditions require management of the underlying condition. HDL cholesterol is a lipoprotein synthesized in the liver, with a normal range of 1.16-1.55 mmol/L. It can transport cholesterol from the tissues outside the liver to the inside for metabolism, and then excrete it with bile, which is anti-atherosclerotic. When HDL cholesterol is high, consider physiologic and pathologic increases. Physiological can be seen in exercise, alcohol consumption, taking drugs (lipid-lowering drugs, contraceptive pills, etc.), generally do not need special treatment; pathologic increase can be seen in chronic hepatitis, chronic toxic diseases, etc., generally only need to deal with the original disease. HDL cholesterol is a beneficial protein, and high levels help prevent coronary heart disease. When dyslipidemia occurs, it is recommended to consult a doctor in a timely manner, under the guidance of the doctor, reasonable and standardized treatment.