Valsartan amlodipine and sildenafil are usually not taken at the same time. 1. Valsartan amlodipine: belongs to the compound preparation, after taking it, it can reduce the extracellular calcium ions, enter into the vascular smooth muscle cells, reduce the contractile response of the resistance blood vessels, as well as inhibit the vasoconstriction. It is mainly used in the treatment of essential hypertension. Usually the drug may cause palpitations, diarrhea, nausea and other discomforts after taking it. And it is contraindicated for those who are allergic to the components of the drug, hereditary angioedema. Liver and kidney function and blood pressure should be monitored during the administration of the drug. Pregnant and lactating women should use the drug under medical supervision. 2. Sildenafil: It is a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5, which can relax the smooth muscle in the corpus cavernosum and lead to blood inflow, thus enabling the penis to become erect and complete sexual intercourse. It is mainly used to treat diseases such as erectile dysfunction. Usually the drug may be taken with angina, hypotension, postural hypotension, heart failure and other discomforts. If co-taken with anti-hypertensive drugs, it may lead to lower blood pressure causing hypotension, so co-taking is not recommended. In summary, valsartan amlodipine tablets and sildenafil after taking at the same time, may make the blood pressure appears to be lowered, thus causing low blood pressure, so it can not be taken at the same time, the above medication needs to be used under the guidance of a doctor.