Wake up at 4 to 5 o’clock in the morning may be a normal biological clock, may also be caused by stress, environmental changes and other physiological factors, may also be neurasthenia, depression or asthma and other diseases. 1. Physiological factors: Because everyone’s biological clock is different, some people used to wake up at 4 to 5 o’clock in the morning, is the normal situation. Secondly, mental overstress, change of living environment may lead to 4 to 5 o’clock in the morning to wake up, is a normal phenomenon. 2. Neurasthenia: neurasthenia is caused by mental tension or stress, the cause of the disease may be related to mental work, psychological factors, etc., the patient will be easy to brain fatigue, mental excitement and other symptoms, some of the patients are excited at night to aggravate the symptoms, affecting the sleep, which may lead to wake up at 4 to 5 o’clock in the morning. 3. Depression: depression is one of the typical cases of depressive disorders, the cause of which is mainly related to genetic factors, neurobiochemical factors and psychosocial factors, etc. Clinical manifestations include depressed mood, slow thinking, and symptoms such as dreaming or waking up early. 4. Other diseases: Asthma, gout and other diseases can attack at night, leading to patients waking up at 4 to 5 o’clock in the morning. There are many reasons for waking up at 4 to 5 o’clock in the morning. After eliminating the physiological factors, patients are advised to consult a doctor for examination to clarify the cause of the disease.