Eczema on hands without pain or itching is an atypical symptom, and may also be caused by oral antihistamine medication. Eczema is an inflammatory disease of the superficial dermis and epidermis caused by internal and external stimuli. Acute eczema is dominated by herpes papules, and there is a clear tendency to ooze, while chronic eczema may cause mossy skin and recurring episodes. Eczema on the hands is painless and itchy, and is considered an atypical symptom of eczema, but treatment should be based on the cause. First of all, find the cause and avoid re-exposure, the body if there is a chronic infection foci or chronic disease, should be actively treated. Zinc oxide ointment and other drugs can be used externally, along with glucocorticoid ointment to improve local symptoms. If the itching symptoms are obvious, you can use topical antihistamine drugs to stop itching treatment, such as loratadine, etc. So after the use of antihistamine drugs, eczema on the hands can also be painless and itchy. Despite the fact that eczema on the hands is painless and itchy, it is still recommended that patients actively seek medical attention and follow the doctor’s instructions for treatment.