Thigh soreness at night difficult to sleep, generally may be due to strenuous exercise, lumbar disc herniation, varicose veins of the lower extremities and other conditions. 1. Strenuous exercise: infrequent exercise, daytime suddenly after strenuous exercise, may lead to leg muscle strain, excessive acidic metabolic products within the muscle, can not be eliminated in a timely manner, resulting in thigh soreness and swelling at night difficult to sleep. 2. Lumbar disc herniation: Lumbar disc herniation may be caused by lumbar disc injury, heredity, lumbosacral congenital developmental abnormalities and other factors, this disease may compress the sciatic nerve, resulting in thigh soreness and bloating at night hard to sleep. 3. Varicose veins of the lower extremities: varicose veins of the lower extremities may be genetically related, but also due to increased venous pressure caused by the obstruction of the veins will lead to the lower extremities blood flow is impeded, resulting in thigh soreness and bloating difficult to sleep at night, and in severe cases will lead to the emergence of earthworm-like vein bulges. There may be other reasons for thigh soreness, such as metabolic abnormalities, heart and kidney failure, etc. It is recommended that the patient go to the hospital in time to find out the specific cause of the disease and treat it.