We would like to remind you that the sudden discontinuation of certain medications when taken for a long period of time is likely to cause a relapse or “rebound” of the original disease, or even accidents, and in severe cases, death. The usual work and life we often encounter some patients think that when the condition is under control, the symptoms are relieved when you can stop taking medication. Typical is some high blood pressure patients, once the blood pressure is effectively controlled, they take the initiative to stop the drug. However, we would like to remind you that some drugs in the long-term use of drugs suddenly stop, it is likely to cause the recurrence of the original disease or “rebound”, or even accidents, serious cases can lead to death, so are taking the drug can immediately stop, should listen to the doctor or pharmacist’s advice, under their guidance to reduce the amount of or to stop taking, to avoid direct and sudden Stop the drug to avoid some adverse consequences. Below we will look at those drugs can not suddenly stop. 1, cardiovascular system medication Cardiovascular system disease patients taking anti-angina drugs, anti-hypertensive drugs and anti-arrhythmic drugs, must not be arbitrarily interrupted or stopped. Antianginal drugs, if arbitrarily interrupted, can easily lead to angina attacks, or even cause myocardial infarction. If the drug is suddenly stopped when the blood pressure is reduced to normal, the blood pressure can rise sharply in a short period of time, even exceeding the pre-treatment level, and symptoms of hypertensive crisis such as dizziness, headache, and blurred vision can occur. Suddenly stop antiarrhythmic drugs can lead to serious arrhythmia, even induced atrial fibrillation, life-threatening. 2, hypoglycemic drugs If you stop using hypoglycemic drugs immediately after your blood sugar has been effectively controlled, it is likely that your blood sugar will rise abruptly and worsen your condition. In particular, the usual application of insulin treatment patients, treatment is effective if the sudden discontinuation of insulin, ketoacidosis coma may occur. 3, glucocorticoid drugs Long-term use of prednisone, dexamethasone and other glucocorticoid drugs, so that the patient’s adrenal cortex function decline, corticosteroid secretion function is inhibited, if this time to suddenly stop or reduce the amount of too fast, can make the condition of the “rebound” phenomenon, such as the occurrence of infections, trauma, hemorrhage, etc., will trigger the adrenal crisis, and even the occurrence of adrenal crisis. If infection, trauma, bleeding, etc. occur, it will induce adrenal crisis and even lead to death by accident. 4, anti-chronic hepatitis B virus drugs patients taking nucleoside antiviral drugs anti-hepatitis B virus treatment, must follow the doctor’s instructions, do not stop the drug without authorization, if the sudden stopping of the drug is likely to induce acute exacerbation of liver disease, or even liver failure. Therefore, patients taking these drugs must not stop taking them without authorization, and should be monitored regularly, whether it is to choose drugs, change the treatment plan or stop taking the drugs should be carried out under the guidance and supervision of specialized doctors. 5, antibiotics and anti-tuberculosis drugs Many antibiotics, when the fever, fatigue and other symptoms of infection disappeared immediately stopped, but in fact at this time the bacteria have not been completely removed. At this time, if the patient thinks that the medicine is over and stops taking the medicine without authorization, the result will lead to recurrence of the disease, deterioration and bacterial resistance. The treatment of tuberculosis also requires a longer course of combination chemotherapy, even the currently recognized short course of chemotherapy requires a six-month course of treatment, which should not be discontinued in the middle of the course. These drugs should follow the principle of “combination, regularity, full course, and proper dosage” in order to improve the therapeutic effect, reduce the development of drug resistance, and thus reduce the recurrence of the disease. Unstandardized anti-tuberculosis treatment can lead to drug-resistant tuberculosis and systemic tuberculosis, which will bring difficulties in treatment. 6, antidepressants and sedative-hypnotic drugs Long-term patients taking antidepressants can not be suddenly discontinued without authorization, should be under the guidance of a doctor to gradually reduce the amount of drugs, stop or change the treatment program, after the sudden cessation of medication, there will be nausea, vomiting, dizziness, headache, muscle pain, anxiety and other symptoms. Depression is a chronic disease with a tendency to relapse. If treatment is inadequate and relapses increase, it will not only increase the difficulty of treatment, but also cost more time and money. Long-term use of sedative-hypnotic drugs such as Valium, such as the sudden withdrawal of drugs, there will be anxiety, excitement, tremor, muscle twitching, headache, gastrointestinal dysfunction, anorexia, perceived allergies, seizures and other symptoms. 7, antiepileptic drugs If you stop taking antiepileptic drugs suddenly, you are likely to experience withdrawal reactions, manifested as: convulsive seizures, anxiety, irritability, panic, sleep difficulties, sweating, abdominal pain, vomiting and inattention. It is important to note that the convulsive seizures here are due to a withdrawal reaction from the medication, not a recurrence of the original seizure. The convulsions in the withdrawal reaction can sometimes be severe and even appear as a grand mal seizure continuum. Withdrawal reactions can usually be avoided if the medication is stopped gradually and slowly. Therefore, when considering stopping the drug, it is necessary to gradually reduce the drug under the guidance of the doctor. If you change to other new drugs in the process of using the drug, the original drug should not be stopped abruptly, but should be taken at the same time with the new drug for a period of time and then gradually reduce the dosage, and only after the condition is completely under control, can the drug be completely stopped. 8, oral long-acting contraceptive pill After taking long-term contraceptive pills, there is a certain accumulation in the body, can not suddenly stop the drug, must be changed to short-acting contraceptive pills for three months before stopping the drug, so as to make the body’s hormone levels slowly decline, to avoid hemorrhage.