Lower extremity arterial occlusive disease is becoming more prevalent in diabetic patients, and based on the patients we see at our hospital, it is one of the leading causes of diabetic foot gangrene (mostly dry gangrene). Many of the current treatments are endoluminal interventions in vascular surgery, but I caution that there is a risk of recurrence with this approach, so a comprehensive evaluation is needed based on the patient and individual condition. First of all, it must be affirmed that endoluminal intervention or stent placement for the treatment of arterial vascular occlusive disease can effectively unblock blood vessels and has the advantages of being minimally invasive, safe and effective, making it the preferred treatment for lower extremity atherosclerotic occlusive disease, however, the incidence of in-stent restenosis after stent implantation is high. There are really many causes of in-stent restenosis, and the patient’s own etiology includes hypertension, hyperlipidemia, exercise, smoking, and medication compliance, in addition to diabetes. There are also the characteristics of the method itself, mainly the intimal hyperplasia caused by the repair process after the damage to the intima of the vessel caused by balloon dilation is considered the main cause, as well as the remodeling of the vessel wall caused by vasoactive substances and hemodynamic changes. Once this condition is occluded again, the difficulty of treatment will increase accordingly, and some patients will undergo further surgery, or intraluminal drug application, and intraluminal thrombolysis, which in any case will have a significant impact on the patient. Moreover, if the patient already has an ulcer in the lower extremity, according to real cases in our hospital it will be correspondingly more difficult to treat gangrene because the ischemic symptoms will be aggravated. As far as we can see, the combination of Chinese and Western medicine significantly makes up for this deficiency in the treatment of peripheral vascular disease, especially the treatment with Chinese herbal medicine, which has fewer complications, less chance of recurrence, more lasting effect, and more importantly, does not have the result of aggravating the lesion after recurrence like intracavitary treatment. Especially for the treatment of diabetic foot, a guideline on the combination of Chinese and Western medicine in the treatment of diabetic foot was released a while ago at the 4th Diabetic Foot Forum in Central China, pointing out that “there are many types of Chinese medicine commonly used clinically in the treatment of diabetic limb vascular lesions, which can be selected appropriately according to different stages of the disease.” This confirms the effectiveness of TCM treatment. In general, I also recommend the combination of Chinese and Western medicine, and have been using this method of treatment. However, regardless of Chinese medicine, Western medicine or interventional methods, the best treatment strategy should be adopted according to the different characteristics of patients and individual conditions, weighing the advantages and disadvantages, compensating each other, minimizing or avoiding potential complications, and allowing patients to heal early.