Oxyfloxacin allergy can cause drug dermatitis, which can appear as erythema, papules, or even vesicles and exudation around the body, accompanied by a certain itching as such. For treatment, if the rash is densely distributed, it is necessary to administer 200 ml of compound glycopyrrolate monoammonium S chloride injection once a day. If the above treatment is not satisfactory, glucocorticoids such as methylprednisolone injection or dexamethasone injection should also be given. And combined with oral levocetirizine hydrochloride capsule one capsule a day and night, as well as orotadine hydrochloride tablets one capsule in the morning and one capsule in the evening for treatment. Topical medication can be applied with mometasone furoate cream, once a day at night. For patients during the treatment period to avoid alcohol, spicy and irritating foods, to avoid again oral, topical, or static doses of ofloxacin, to avoid further aggravation of the rash.