Toenail into the flesh and pus, can take drug treatment and surgical treatment. 1. Drug treatment: because the patient already has pus symptoms belong to the middle degree of infection, it is recommended to take the specimen to do the culture of the first empirical antimicrobial drug treatment, and then according to the bacterial culture and drug sensitivity results, and then adjust the antimicrobial drug program. Acute purulent infections are mostly staphylococcus, hemolytic streptococcus and other infections, can use amoxicillin, cephradine and so on. 2. Surgery: for acute purulent toe infection with obvious throbbing pain, swelling, general discomfort should be incised and drained, so as to avoid necrosis and osteomyelitis of the toe bone. Surgery generally adopts local anesthesia, the pus cavity is large suitable for counterpart drainage, there are dead bones need to remove the dead bone. After surgery, the patient should be immobilized in a functional position, and functional exercises should be performed during the recovery period after infection control. It is recommended that patients go to regular hospitals for treatment in a timely manner, and should not blindly use medication on their own, so as not to delay the condition and cause serious consequences.