Thrush in infants is a fungal infection that usually does not heal on its own and medication is recommended under medical supervision. Thrush is a Candida albicans infection that forms a white discoloration on the surface of the oral mucosa and usually does not heal on its own. It is most common in newborns and infants. It is characterized by white milk clot-like dots or small flakes covering the surface of the oral mucosa, which can gradually fuse to form a large area and cannot be easily wiped away, with no inflammatory reaction in the surrounding area. No pain, no salivation, usually does not affect the milk, no systemic symptoms. Generally do not need oral antifungal drugs. 2% sodium bicarbonate solution can be used to clean the mouth before and after breastfeeding, or local application of 100,000~200,000U/ml mycophenolic solution, 2~3 times a day. Oral intestinal microecological agents can also be taken to inhibit fungal growth. Prevention should pay attention to breastfeeding hygiene, strengthen nutrition, and increase vitamin B2 and vitamin C appropriately. All of the above drugs should be used under the guidance of a doctor, avoid self-medication.