The causes of palm swelling and pain are mainly considered to be related to inflammation of the metacarpophalangeal joints, degenerative diseases, neurological lesions and prolonged poor posture. 1. Inflammation of the metacarpophalangeal joints: If there is inflammation in the joints of the fingers, such as metacarpophalangeal arthritis, the stimulation of inflammation will lead to an increase in exudate, which will easily lead to the symptom of palm distension and pain. 2. Degenerative lesions: usually if you often use the palm of the hand to generate the problem of degenerative joints of the palm joints, it is easy to cause localized swelling and pain, and even accompanied by symptoms of limited joint activity. 3. Neurological lesions: If there is a peripheral nerve injury in the upper limbs or the presence of nerve root cervical spondylosis, it is easy to affect the sensation of the palm area, thus triggering the symptoms of palm distension and pain. 4. Prolonged poor posture: usually, if you often hang down your arm or poor posture affects the blood return to the palm of the hand, it is easy to produce the phenomenon of congestion in the palm of the hand, thus triggering the symptoms of palm distention and pain. If the swelling and pain in the palm of the hand lasts for a long time, you can go to the orthopedic department for examination, and then under the guidance of the doctor to carry out targeted treatment to prevent the later generation of motor dysfunction.