Whether creatinine will rise after stopping medication for uremia depends on whether or not renal replacement therapy such as hemodialysis or peritoneal dialysis is performed. If there is no renal replacement therapy, creatinine may rise after stopping the drugs to protect renal function; if there is renal replacement therapy, creatinine usually does not rise after stopping the drugs. If you are not on renal replacement therapy such as hemodialysis and peritoneal dialysis, and stop using all the renal protection and detoxification drugs, your creatinine may increase, and your condition may even deteriorate gradually, and you may easily develop various complications, which may be life-threatening in serious cases. If you are already on renal replacement therapy with adequate weekly dialysis, creatinine usually does not rise after stopping the drugs. Patients with uremia are advised to go to regular hospitals in time and receive standardized treatment under the guidance of doctors.