Helicobacter pylori is generally not self-curable, and some children can recover from the infection. It is necessary to receive anti-infection treatment with quadruple therapy according to the condition. Helicobacter pylori is a kind of hardy bacteria, most of them are colonized in the gastric mucosa, and can tolerate high acid environment, so it is difficult for adults to be infected with Helicobacter pylori. Some children can recover spontaneously after infection, and the mechanism is not yet known. Patients are advised to receive early anti-infective treatment, which generally requires a quadruple therapy to remove H. pylori. These four drugs include bismuth potassium citrate, amoxicillin, omeprazole, and clarithromycin. One month after the eradication of H. pylori and discontinuation of the medication, the 13C breath test will need to be repeated to determine if it has been eradicated. If resistance exists or the bacteria have not been cleared, the patient will need to be treated again with quadruple therapy. In addition, the above medications are recommended to be treated under the guidance of a specialist.