How to treat shoulder pain caused by bone metastasis of lung cancer can consider drug, surgery, radiotherapy and other treatments. Pain caused by bone metastasis of lung cancer can be treated with medication, including bisphosphonates and opioid painkillers, which can improve the quality of life of patients. Those who are able to undergo surgery can also consider complete surgical resection, or if there is pathological fracture, active local immobilization is needed, which can reduce patients’ pain and improve their quality of life. For those who are too old to undergo surgery, radiotherapy can be used to control the progress of the disease and alleviate the pain symptoms of patients, and the adverse effects are usually relatively mild. Therefore, how to treat shoulder pain caused by bone metastasis of lung cancer can be considered as comprehensive treatment, and the best treatment method can be chosen according to the patient’s condition.