The causes of blisters around the anus consider the following: 1. Fixed drug rash: due to long-term use of antipyretic and analgesic drugs as well as anticoagulant drugs, purplish red spots appear around the anus and genitals, and blisters on the red spots, accompanied by pain. In the treatment, first stop taking allergy-causing drugs, you can take oral compound glycopyrrolate tablets and Epastine tablets, if it is rice-like blisters, you can apply Furfuryl Glycolate lotion topically, if the blisters rupture, you can apply local compound Phellodendron lotion for cold wet compresses, recombinant human epidermal growth factor gel and zinc oxide oil mixed with topical application. 2. Herpes zoster in the anus: this is a kind of varicella-zoster virus caused by The main reason for this is that it is a sexually transmitted disease, mainly through sexual contact, in the anus and around the genitals can be seen erythema, papules, clusters of blisters, unilateral distribution, and accompanied by significant pain. If the blisters are not broken, you can apply penciclovir cream, if the blisters are broken, you can apply comfrey oil and fusidic acid cream alternately, if the pain is obvious, you can take oral pregabalin capsules, during the treatment period, you should avoid spicy and stimulating food, alcohol, water and sitz bath. For blisters around the anus, it is recommended that patients go to a regular hospital and under the guidance of a dermatologist, undergo appropriate laboratory tests to guide clinical treatment.