Alcohol baths are a very common clinical method of physical cooling and are safe and effective. It has a very good antipyretic effect according to the volatile characteristics of alcohol to take away the body heat and thus reduce the body temperature. Clinically used bath wipe order: upper extremity: lateral neck → lateral upper extremity → back of the hand; lateral chest → axilla → medial upper extremity → palm; the same method wipe the other side of the upper extremity. Dorsolumbar region: patient lying on his side, wipe for 3 min; lower extremity: iliac bone → lateral lower extremity → dorsal foot; inguinal → medial lower extremity → medial condyle; inferior femur → popliteal fossa → heel. Wipe the other side in the same way, each limb for 3 min. wipe the other side in the same way. Avoid rubbing the precordial area (can cause slow heart rate or arrhythmia), abdomen (can cause diarrhea), posterior neck, and foot area (can cause transient coronary artery constriction) to avoid adverse reactions. Because of the rapid evaporation of alcohol, it can be repeatedly applied to lower the body temperature according to the patient’s body temperature. Also note that alcohol and some drugs can produce disulfiram-like reactions, so the clinical application of cephalosporins and other drugs to avoid the application of alcohol physical cooling, to avoid adverse reactions.