Whether newborns with high C-reactive protein can go down on their own depends on the cause of the disease. Mildly high C-reactive protein caused by minor infections can recover on their own; while high C-reactive protein caused by serious infections, autoimmune diseases, tumor diseases, etc. generally requires treatment to return the C-reactive protein to normal. Bacterial and other microbial infections can cause increased C-reactive protein, generally mild infections and high C-reactive protein can be eliminated by the baby’s own resistance to pathogens, so that the C-reactive protein value returns to normal. If the infection is more serious, and due to the low resistance of newborns, it is generally less likely to recover on its own. Severe infections, autoimmune diseases, oncological diseases and other causes of high C-reactive protein in newborns often can not return to normal on their own, and need systematic and regular treatment to eliminate the body’s inflammatory response before the newborn C-reactive protein value can return to normal. Newborns with high C-reactive protein should go to the neonatology department of the hospital in a timely manner to improve the examination, to clarify the cause of the disease and then give targeted treatment.