Cefixime and amoxicillin are both antibiotic drugs, the two drugs have similarities, but there are some differences in the chemical structure and antibacterial spectrum, under the guidance of the physician, the safety of the two drugs are relatively good, can not simply say that which drug is safer. 1. Cefixime is a third-generation cephalosporin, with a broad antibacterial spectrum, a variety of bacteria can play a good antibacterial activity, can prevent the synthesis of the bacterial cell wall to achieve the purpose of antibacterial, can be used for sensitive bacteria caused by infectious diseases. 2. Amoxicillin belongs to the penicillin class of antibiotic drugs, on a variety of aerobic gram-positive cocci, gram-negative bacteria and Helicobacter pylori can play a good antibacterial effect. It is not possible to compare the safety of cefixime and amoxicillin purely because there are many similarities between the two drugs themselves. ADVERSE REACTIONS: The main adverse reactions caused by cefixime include diarrhea, rash, and eosinophilia. Amoxicillin causes common adverse reactions of rash, nausea and diarrhea. CONTRAINDICATIONS: Both cefixime and amoxicillin need to be contraindicated in people who are allergic to the drugs. Contraindications to the use of amoxicillin include patients with infectious mononucleosis, and patients with asthma, eczema, and urticaria. Individuals need to use cefixime and amoxicillin under the supervision of a physician to increase the safety of use and not abuse the drug.