The factors that make the tissue fluid generation decrease mainly include the increase of plasma colloid osmotic pressure, the decrease of plasma hydrostatic pressure, and the decrease of capillary permeability. 1. Increase in plasma colloid osmotic pressure: the plasma colloid osmotic pressure mainly regulates the fluid balance inside and outside the blood vessels, which is mainly provided by a variety of proteins in the blood. When the plasma colloid osmotic pressure increases, the gravitational pull of the blood on water is strong, and the fluid that exudes out of the blood vessels will be less, and the generation of tissue fluid will be reduced. 2. The hydrostatic pressure of plasma: it can be understood as the blood pressure of capillaries, when the hydrostatic pressure decreases, the force of water discharged to the outside of the blood vessels decreases, and the generation of tissue fluid also decreases. 3. Capillary permeability is reduced: capillary permeability is reduced, through the capillary protein is reduced, the plasma colloid osmotic pressure increases and the tissue fluid colloid osmotic pressure decreases, then the plasma water attraction is stronger than the tissue fluid, tissue fluid generation is reduced. When the body has symptoms related to water shortage, should be timely consultation, active treatment, so as not to miss the disease.