Fever with cold hands and feet and heat, occurring at different stages of the disease process, cold hands and feet often occur in the early stage of fever and high fever stage. 1. Early stage of fever: the patient’s body is feverish and his hands and feet are cold, mostly because after bacteria or viruses invade the human body, they produce inflammatory factors that act on the regulatory center of body temperature, resulting in dysfunction of heat production and heat dissipation, and the patient has the symptom of coldness (fear of cold, cold limbs), which causes cold hands and feet. Patients can relieve cold hands and feet by soaking their feet and applying hot compresses with warm water bags. 2. High fever stage: As the patient’s body temperature rises, the capillary blood around the body expands, resulting in fever in the hands and feet and the whole body. In this case, you need to consult a doctor in a timely manner, under the guidance of the doctor can take oral antipyretic drugs, such as p-ethylaminophenol, to relieve the symptoms. Patients with fever with cold and hot hands and feet must seek prompt medical attention and follow the doctor’s instructions.