Holding back more urine will not get uremia, but often hold back urine will be easy to get urinary tract infections. At present, the most common causes of uremia in China, is still mainly chronic glomerulonephritis, other causes that may lead to uremia are as follows: 1, secondary glomerulonephritis, such as diabetic nephropathy lupus nephritis, uric acid nephropathy, hypertensive renal damage, as well as ANCA-associated small vasculitides renal damage, multiple myeloma. 2, hereditary glomerular diseases, such as polycystic kidney, Alport syndrome, etc. Patients with uremia will lead to volume, acid-base, electrolyte imbalance, as well as systemic organ failure, endangering the patient’s life, patients with uremia need to perform renal replacement therapy to maintain life.