Amlodipine benzenesulfonate can be combined with hydrochlorothiazide tablets, but be careful to prevent electrolyte disorders. The mechanism of action of amlodipine benzenesulfonate is to inhibit calcium ion inward flow, which has a dilating effect on peripheral blood vessels and can reduce arterial blood pressure. Hydrochlorothiazide tablets belong to diuretics, through diuretic effect can reduce blood volume, also has the effect of reducing blood pressure. For the oral amlodipine benzenesulfonate is not effective patients, can be combined with hydrochlorothiazide tablets, but be aware of hydrochlorothiazide can lead to electrolyte disorders. Adverse reactions of amlodipine benzenesulfonate include lower limb edema, tachycardia, facial flushing, dry stools, etc. It is contraindicated in patients who are allergic to the components of the drug and have severe hypotension. Adverse reactions to hydrochlorothiazide include thirst, nausea, vomiting, fatigue, electrolyte disorders, etc. It is contraindicated in patients who are allergic to the components of the drug. When amlodipine benzenesulfonate and hydrochlorothiazide tablets are used together, it is necessary to pay attention to strengthening the monitoring of electrolytes and choosing a treatment plan under the guidance of a physician.