The burning sensation of male ejaculation is usually related to seminal vesiculitis, urethritis, vasculitis and other diseases, according to different causes of oral cephalosporin antibiotics, quinolone antibiotics, penicillin antibiotics and so on. 1. Spermatitis: When acute vesiculitis is triggered, it will cause a burning sensation in ejaculation, which can be applied to clarithromycin, ciprofloxacin, cephalosporin, etc., and the specific use of what drugs should be in accordance with the doctor’s instructions. 2. Urethritis: If infected with gonococcus and non-gonococcus caused by urethritis, the causative organisms repeatedly stimulate the urethral tissues will affect the ejaculation, resulting in ejaculation with burning sensation. About the disease should be antibacterial as the principle of treatment, clinically can take azithromycin, doxycycline, ceftriaxone and so on. 3. Vasovaginitis: mainly refers to the inflammation occurs in the vas deferens, affected by inflammation, ejaculation also occurs abnormally, manifested as burning and tingling. Levofloxacin, enrofloxacin, moxifloxacin and other drugs can be applied, and the specific need to choose the appropriate drugs according to the type of pathogen infected. Men with burning sensation in ejaculation, when choosing oral antibiotics, must be under the guidance of doctors, avoid unauthorized use of drugs.