Topical medications for the treatment of anal fissure include analgesic medications, vasodilators, calcium channel blockers, and so on. 1. Analgesics: For anal fissure patients with pain, analgesic drugs such as lidocaine gel can be used locally to relieve discomfort. 2. Vasodilator: patients with anal fissure can also use local nitroglycerin ointment to improve blood circulation and promote healing. However, it should be noted that the drug is easy to lead to low blood pressure, headache and other adverse reactions, long-term use is not recommended. 3. Calcium channel blockers: patients can also use topical diltiazem, nifedipine and other calcium channel blockers to relieve symptoms. This kind of drug is easy to relapse after treatment. It is recommended that patients use reasonable medication under the guidance of a doctor, and take measures such as surgery for treatment if necessary, so as not to delay the condition or cause discomfort.