Whether or not liver injury is severe at a direct bilirubin of 8.5 μmol/L should be determined based on a combination of the specific disease and other test results. If the patient’s direct bilirubin is 8.5 μmol/L due to cholecystitis, benign gallbladder polyps, smaller gallbladder stones, and intrahepatic bile duct stones, etc., the patient’s condition may improve and the direct bilirubin may return to normal after timely treatment because all of them are benign, indicating that the liver injury is not too serious. If it is caused by hepatocellular carcinoma or decompensated cirrhosis, the symptoms may improve significantly after treatment, but it is not possible to achieve a curative effect, and the direct bilirubin is less likely to be restored, indicating that the liver injury is relatively more serious. At the same time, the degree of liver damage also needs to be combined with the comprehensive judgment of glutamic oxal transaminase and glutamic oxal transaminase. If the patient’s test result is direct bilirubin 8.5 μmol/L, he should go to the regular hospital in time, after clarifying the cause of the disease, and then carry out targeted treatment under the guidance of the doctor to minimize the adverse effects of the disease.