The causes of hand numbness, hand swelling and hand tightness after waking up are many, and are related to cervical spondylosis, cerebrovascular disease and peripheral neuropathy. 1. Cervical spondylosis: It is mainly related to spinal cord cervical spondylosis. Long-term strain on the cervical vertebrae, herniated intervertebral discs and thickened ligaments lead to pressure on the spinal cord and nerve roots, resulting in pain or numbness of the upper limbs, hand swelling, hand tightness and inflexibility. 2. Cerebrovascular disease: cerebrovascular disease often has vascular sclerosis, insufficient blood supply, cerebral ischemia and hypoxia, etc., which will make the patients have the symptoms of numbness, hand swelling and hand tightness after waking up. Transient ischemic attack can cause paroxysmal numbness and weakness on one side of the body. 3. Peripheral neuropathy: If diabetic patients have peripheral nerve damage, patients will experience numbness, swelling, tightness, coldness and other sensations in the endings of the extremities. Waking up with numbness and swelling of the hands and tightness of the hands may have other causes such as rheumatoid arthritis, improper sleeping posture, rheumatoid arthritis, etc., it is recommended to go to the hospital in a timely manner to improve the examination, to clarify the cause of the disease.