Atrophic gastritis caused by Helicobacter pylori can be improved by eradicating Helicobacter pylori and reversing the atrophic gastric mucosa, and the specific efficacy varies from person to person. Atrophic gastritis can progress to gastric cancer to a certain extent, and H. pylori infection is an important cause of these two diseases. Therefore, the first and foremost means of treating atrophic gastritis and preventing it from progressing to gastric cancer is the eradication of H. pylori. Currently, four combinations of drugs (proton pump inhibitor + bismuth + 2 antibiotics) are often recommended for the eradication of H. pylori, such as esomeprazole + bismuth colloidal pectin + amoxicillin + furazolidone, and the recommended duration of treatment is 10~14 days. Those who experience few adverse effects and can tolerate the medication can try to use it for 14 days. The results of the treatment should be reviewed after 1 month of drug withdrawal at the end of the treatment. For those who are successfully treated with eradication therapy and still have symptoms related to gastric discomfort, drugs such as omeprazole can be taken as appropriate to alleviate the symptoms. Specific medication should be administered under the guidance of a specialist and should not be used without authorization.