Halitosis caused by Helicobacter pylori is primarily treated with medication. If the condition is more severe, surgical treatment may also be required. A quadruple regimen can be used clinically to eradicate H. pylori from the body. It mainly consists of a proton pump inhibitor, bismuth and two antibiotics such as omeprazole, amoxicillin, clarithromycin and bismuth potassium citrate. The course of treatment is 10-14 days. Patients need to take the relevant medications in full dosage and course of treatment in strict compliance with the doctor’s prescription. If Helicobacter pylori infection not only causes bad breath, but also leads to intractable ulcers, compound ulcers, acute perforation, etc., the patient needs to actively cooperate with the doctor to undergo surgical treatment, so as not to jeopardize life and health.