Generally speaking, a gecko’s body fluids do not require a rabies vaccine when the toe is touched. The purpose of the rabies vaccine is to minimize the chance of infection with the rabies virus, which is highly lethal when it enters the body through broken skin or mucous membranes and causes rabies. The virus is transmitted by infected carnivorous mammals, commonly domesticated and stray cats, dogs, and bats, but generally not through the bodily fluids of geckos. Geckos are not mammals, but reptiles, and there are no conclusive studies showing that the rabies virus can be transmitted through these animals, so when a toe comes into contact with gecko fluids, it is usually sufficient to rinse it off with water and rabies vaccination is not required. If the toe happens to have a wound, and the body fluid enters the wound and causes redness, swelling, tingling and other symptoms, then you need to go to the hospital in time for treatment.