Low total cholesterol caused by taking lipid-lowering drugs, generally reduce the dosage or stop the drug, switch to other drugs, the symptoms will be gradually relieved; but if it is caused by malnutrition during the period of medication, some improvements should be made from the aspect of diet. 1. Drugs: If it is determined that long-term use of drugs lead to low total cholesterol, under the guidance of the doctor can be discontinued or reduce the amount of drugs until the cholesterol returns to normal level. However, if the above methods can not be relieved, it is necessary to switch to other drugs to reduce total cholesterol, such as atorvastatin, resuvastatin and so on. 2. Malnutrition: If the diet is not enough to keep up with the nutrition during the medication period, resulting in malnutrition, it will also lead to low total cholesterol. In this case, you need to make some improvements in diet, to ensure a balanced diet, it is recommended to eat more protein, calcium-rich foods, such as fish, shrimp, beef and so on. In the process of taking lipid-lowering drugs, cholesterol needs to be checked regularly, and then adjust the dosage as well as the treatment program according to the individual’s situation, which should be carried out under the guidance of professional physicians.