Redness, swelling and special pain after using imiquimod cream is an adverse reaction or allergy symptom, which can be relieved and treated by topical medication and oral antihistamine. 1. Adverse reactions: imiquimod cream will appear after the use of a series of adverse reactions, at this time you need to stop using the drug in a timely manner, the use of water to rinse the affected area, after stopping the drug, redness, swelling and pain will gradually ease the symptoms. If the redness, swelling and pain is particularly serious, and there is ulceration phenomenon, can be coated with recombinant human epidermal growth factor gel treatment. 2. Allergic symptoms: redness, swelling and pain may also be an allergic reaction to therapeutic drugs, the need to use antihistamines for anti-allergy treatment, commonly used drugs are loratadine tablets, cetirizine hydrochloride tablets, fexofenadine tablets, etc., which can promote the absorption of inflammation subsides, and is conducive to the improvement of itching and redness. It is recommended that patients seek timely medical treatment, actively cooperate with the doctor’s treatment, do not self-medication.