The proper administration of folic acid requires attention to symptomatic use, avoidance of contraindications, monitoring of adverse reactions, and use of medication under the direction of a physician. Normal people can obtain enough folic acid through food and so on, without special supplementation. Folic acid is mainly used to prevent fetal congenital neural tube malformation, folic acid deficiency megaloblastic anemia and other diseases. Folic acid is usually taken from the first trimester of pregnancy until the end of pregnancy to prevent neural tube malformations, and megaloblastic anemia is taken until the condition improves. In the course of taking the drug, if there is a decrease in appetite, resistance to eating, nausea, abdominal discomfort and other adverse reactions, it is recommended to go to the hospital in time to consult the doctor, and if necessary, need to stop using the drug. It should be noted that all anemia accompanied by vitamin B12 deficiency is prohibited to supplement folic acid alone, so as not to cause increased burden of vitamin B12 and neurological symptoms. Folic acid needs to be administered under the supervision of a clinician.